Prevention of Ovarian Hyper stimulation Syndrome by using gonadotrophic releasing hormone analogue to induce final ovulation trigger in invitro fertilization cycles

Objectives: To find out occurrence of ovarian hyperstimulation in patients who were hyper responders vitro fertilization cycles. Secondary outcome was to assess number metaphase II oocyte and rate, cleavage rate pregnancy when GnRHa is used for final maturation triggering ovulation. STUDY DESIGN, SIZE, DURATION: This retrospective descriptive analysis cases managed at single center from June 2017 till May 2018. PATIENTS & METHODS: Twenty identified as based on baseline, reserve characteristics, that antral follicle count, (AFC) > 25, AMH 4ng/ml day trigger, follicles >-25 ≥ 11mm administered trigger 1500IU hCG retrieval while luteal phase supported with daily vaginal progesterone twice estradiol valerate. Sixteen underwent fresh transfer four had their embryos frozen. MAIN RESULTS: high risk baseline characteristics were, mean age 31.7 ± 4.50, count 25.7 5.01, Anti Mullerian hormone level 4.64 2.52 PCOS present 35% cases. Peak 13455-± 6632pmol/l 25.45 8.78 confirmed a response. Oocyte yield 11.45+ Metaphase retrieved 85.5% 93%. No case early onset OHSS identified. Only one patient developed moderate OHSS. Pregnancy 31.25%. Miscarriage 6.3% ongoing 25%. CONCLUSION: small supports the view current literature GnRH not only prevents also achieves increase M11 oocytes. In addition, statistically different those cycles where trigger.